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SUMMARY:New Insights into the Mechanisms and Selectivity of Protein Degrad
 ation by the Proteasome Pathway - Professor Alfred Lewis Goldberg
DTSTART:20120515T093000Z
DTEND:20120515T103000Z
UID:TALK38242@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:Fred Goldberg is a Professor of Cell Biology at Harvard Medica
 l School and is visiting Cambridge as a guest of St. John’s College.  \n
 \nFred has been fascinated by protein degradation pathways since his first
  days as a professor at Harvard in the 1970’s. The general opinion at th
 e time was that the cell’s garbage collection was mostly done by the lys
 osome. Always pushing at the frontiers of cell biology\, Fred discovered t
 he proteasome and then it’s famous inhibitor MG-­‐132. With careful c
 hemical manipulations his group was able to generate the related compound 
 bortezomib that is now a billion dollar drug used for the treatment of a h
 aematological cancer called myeloma. \n
LOCATION:Part II Room\, Department of Genetics
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