BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Stabilizing Proteins with Polymer Conjugates - Prof Heather D Mayn
 ard\, Department of Chemistry &amp\; Biochemistry and California NanoSyste
 ms Institute\, University of California
DTSTART:20120531T150000Z
DTEND:20120531T160000Z
UID:TALK38355@talks.cam.ac.uk
CONTACT:Catherine Jordan
DESCRIPTION:Protein-polymer conjugates are a class of materials widely use
 d as drugs.  Covalent attachment of polymer chains to proteins increases t
 herapeutic potential\, and can stabilize proteins to environmental stresso
 rs.  We have utilized controlled radical polymerizations to prepare polyme
 rs for site-specific conjugation to proteins\, as well as to polymerize fr
 om proteins forming conjugates in situ.  Both approaches result in conjuga
 tes where the protein viability is retained.  More recently\, we have deve
 loped synthetic strategies to produce homo- and hetero-telechelic polymers
  for reaction with biomolecules.  The materials have been utilized to prep
 are dimeric and star protein conjugates.  We are interested in these archi
 tectures because conjugate designs that control the number and presentatio
 n of proteins could exhibit higher biological activities than the correspo
 nding monomeric conjugates.  In this talk\, synthetic strategies\, methods
  to stabilize proteins\, and application of the resulting conjugates in na
 nomedicine will be discussed.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
END:VEVENT
END:VCALENDAR