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SUMMARY:How Can One Measure Sodium In Cells\, Tissues\, and In Vivo? - Ale
 xej Jerschow\,  New York University
DTSTART:20120627T100000Z
DTEND:20120627T110000Z
UID:TALK38462@talks.cam.ac.uk
CONTACT:Dr James Keeler
DESCRIPTION:Sodium plays important roles in the body\, such as regulating 
 electrical potentials\, osmotic pressure\, and water content. Monitoring s
 odium levels in vivo by noninvasive NMR and MRI methodology can provide ma
 rkers for early signs of osteoarthritis\, cancer\, brain disorders\, and m
 uscle dysfunction. To overcome obstacles\, such as low sensitivity or shor
 t relaxation times\, inherent for sodium nuclei\, we develop efficient exc
 itation pulse sequences and image readout techniques. Fluid-suppressed sod
 ium MRI has already shown differences between osteoarthritic groups of vol
 unteers and healthy controls in vivo. The methodology can also be used for
  studying cells under stress or cell dysfunctions. Sodium measurements wit
 h JURCAT (T-cell leukemia) cells have revealed intracellular sodium buildu
 p after hyperthermic treatment.
LOCATION:Unilever  Lecture Theatre\,  Department of Chemistry
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