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SUMMARY:Cellular responses to DNA damage:  translating molecular insights 
 towards new cancer therapies - Prof Steve Jackson\, Head of Cancer Researc
 h UK Laboratories The Gurdon Institute\, Cambridge
DTSTART:20121127T120000Z
DTEND:20121127T130000Z
UID:TALK38680@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Inherited or acquired defects in detecting\, signalling or rep
 airing DNA damage are associated with various human pathologies\, includin
 g immunodeficiencies\, neurodegenerative diseases and cancer(1). Work in m
 y "laboratory":http://www.gurdon.cam.ac.uk/~jacksonlab/ aims to decipher t
 he mechanisms by which cells detect DNA damage\, signal its presence and m
 ediate its repair(2). Much of our work focuses on DNA double-strand breaks
  (DSBs) that are generated by ionizing radiation and radiomimetic chemical
 s\, and which also arise when the DNA replication apparatus encounters var
 ious forms of DNA damage. In this talk\, I will summarize how our recent w
 ork has helped to establish how protein complexes assemble and disassemble
  on chromatin at sites of DNA damage and how these complexes promote DNA r
 epair and DNA-damage signalling. I will also explain how our increasing kn
 owledge of cellular DNA-damage responses is providing exciting opportuniti
 es for developing novel treatments for cancer(3). Finally\, I will describ
 e how the Cambridge-based company MISSION Therapeutics (http://www.mission
 therapeutics.com/) plans to exploit these opportunities to produce new\, m
 ore effective anti-cancer medicines.\n\nReferences\n1.	Jackson\, S.P. and 
 Bartek\, J.  (2009).  The DNA-damage response in human biology and disease
 .  Nature 461\, 1071-1078.\n2.	Polo SE and Jackson SP. (2011). Dynamics of
  DNA damage response proteins at DNA breaks: a focus on protein modificati
 ons. Genes Dev. 25\, 409-433.\n3.	Jackson\, SP. (2009). The DNA-damage res
 ponse: new molecular insights and new approaches to cancer therapy. Bioche
 m. Soc. Trans. 37\, 383-394\n
LOCATION:CRI Lecture Theatre
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