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SUMMARY:Multiscale Imaging of the Nervous System: Where is the Dark Matter
  - Mark Ellisman\, Professor of Neurosciences\, Director\, National Center
  for Microscopy and Imaging Research and Center for Research in Biological
  Systems\, University of California at San Diego
DTSTART:20120921T100000Z
DTEND:20120921T110000Z
UID:TALK38949@talks.cam.ac.uk
CONTACT:29071
DESCRIPTION:A grand goal in neuroscience research is to understand how the
  interplay of structural\, chemical and electrical signals in and between 
 cells of nervous tissue gives rise to behavior. We are rapidly approaching
  this horizon as neuroscientists make use of an increasingly powerful arse
 nal of tools and technologies for obtaining data\, from the level of molec
 ules to nervous systems\, and engage in the arduous and challenging proces
 s of adapting and assembling neuroscience data at all scales of resolution
  and across disciplines into computerized databases. This talk will highli
 ght projects where development and application of new contrasting methods 
 and imaging tools have allowed us to see otherwise hidden relationships be
 tween cellular\, subcellular and molecular constituents of nervous systems
 . New chemistries for carrying out correlated light and electron microscop
 y will be described\, as well as recent advances in large-scale high-resol
 ution 3D reconstruction with TEM and SEM based methods. The Whole Brain Ca
 talog (WBC)\, a Google Earth-like open-source virtual model of the mouse b
 rain\, will also be described. The WBC is as an example of an open access 
 bioinformatics framework and web-based tool whose purpose is partly to fac
 ilitate integration of 3D image data from multiple microscopy methods and 
 to enable the linking of information derived from other analytical approac
 hes to imaging data. 
LOCATION:MRC LMB: Max Perutz Lecture Theatre
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