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SUMMARY:Putting things in perspective: multiscale integration of stomatal 
 development  - Dominique Bergmann\, Stanford University and HHMI
DTSTART:20130221T130000Z
DTEND:20130221T140000Z
UID:TALK39043@talks.cam.ac.uk
CONTACT:Jill Harrison
DESCRIPTION:During development\, multicellular organisms create a diverse 
 set of specialized cell types and organize these cells into functional tis
 sues. Often this process involves establishing self-renewing populations v
 ia asymmetric cell divisions. Once established\, these populations must di
 vide and create new differentiated cells at the appropriate rate and in th
 e appropriate place. We use stomata (epidermal structures that regulate ca
 rbon dioxide and water exchange) as a model to understand asymmetric divis
 ions during pattern formation in plants\; stomata guard cells are created 
 via a stereotyped set of asymmetric cell divisions whose number and orient
 ation are dictated by the interplay of cell-type specific transcription fa
 ctors and local cell-cell interactions. Work from several labs over the la
 st decade has identified key regulators of stomatal lineage cell fates. Mu
 ch of the fate specification within the stomatal lineage involves regulato
 ry logic and molecules conserved between plants and animals. The control o
 ver asymmetric divisions and cell morphogenesis\, however\, involves prima
 rily plant-specific elements. Having found footholds into the questions of
  cell polarity and fate\, we hope to move these into a larger context—ho
 w do these key restriction points integrate information from various sourc
 es into a discrete outcome\, and what are the genetic networks surrounding
  these nodes? Current larger-scale projects are to capture cell growth\, d
 ivision and targeted gene expression patterns in stomatal lineage cells as
  a whole leaf develops and to obtain cell-type-specific gene regulation tr
 ends. I will discuss how these approaches interface with focused projects 
 on the targets and regulation of two transcription factors\, SPEECHLESS an
 d FAMA\, and the generation of cell polarity preceding and following asymm
 etric cell division and the themes that emerge when cell fate and developm
 ental flexibility in this lineage relative to other self-renewing populati
 ons in the plant.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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