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SUMMARY:Genetic Dissection of the Fly Visual Course Control - Axel Borst
DTSTART:20121112T163000Z
DTEND:20121112T173000Z
UID:TALK39314@talks.cam.ac.uk
CONTACT:P.H. Marchington
DESCRIPTION:Visual navigation has been studied extensively in flies\, both
  in tethered as well as in freely flying animals. As neural control elemen
 ts\, the tangential cells of the lobula plate seem to play a key role: the
 y are sensitive to visual motion\, have large receptive fields\, and\, wit
 h their spatial distribution of preferred directions\, match the optic flo
 w as elicited during certain types of flight maneuvers. However\, several 
 key questions have remained unanswered for long:\n1. What is the neural ci
 rcuit presynaptic to the tangential cells responsible for extracting the l
 ocal direction of motion? 2. Do the lobula plate tangential cells indeed c
 ontrol turning responses of the fly? 3. Is there a separate visual course 
 control system allowing the fly to detect and track individual objects? I 
 will present recent progress towards answering these questions made by com
 bining whole-cell patch recording and behavioral studies with silencing an
 d optogenetic stimulation of genetically targeted candidate neurons in Dro
 sophila.\n\nReferences.\n\nBorst\, A.\, Haag\, J. & Reiff\, D.F. (2010).  
 Fly Motion Vision. Annu. Rev. Neurosci. 33\, 49–70.\n\nEichner\, H.\, Jo
 esch\, M.\, Schnell\, B. & Borst\, A.  (2011).  Internal Structure of the 
 Fly Elementary Motion Detector.  Neuron 70\, 1155–1164.\n\nJoesch\, M.\,
  Schnell\, B.\, Varija Raghu\, S.\, Reiff\, D.F. & Borst\, A. (2010).  On 
 and Off Pathways in Drosophila Motion Vision.  Nature\, L468\, 300-304.\n
LOCATION:Hodgkin-Huxley Lecture Theatre\, Department of Physiology Develop
 ment and Neuroscience
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