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SUMMARY:The role of topological constraints on condensed polymers and DNA 
 in human cells - Mirny\, L (Massachusetts Institute of Technology\, USA)
DTSTART:20120903T103000Z
DTEND:20120903T111000Z
UID:TALK39494@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Human DNA is two meters long and is folded into a structure th
 at fits in a cell nucleus of just 5 microns in diameter. Recently develope
 d Hi-C technique provides comprehensive information about genome folding. 
 Our analysis of Hi-C data provides and biophysical polymer modeling show t
 hat scaling observed in the data is consistent with non-equilibrium and un
 knotted polymer state  the crumpled (fractal) globule. We demonstrate that
  the fractal globule emerges as a result of polymer collapse and has a sho
 rt lifetime\, rapidly mixing while remaining largely unknotted. Long-time 
 dynamics of a condensed polymer reveals that spatial and topological equil
 ibration happen at vastly different time scales and that topological const
 rains have little effect on relatively short and flexible chains.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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