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SUMMARY:How the genome folds - Lieberman Aiden\, E (Harvard University\, U
 SA)
DTSTART:20120903T095000Z
DTEND:20120903T103000Z
UID:TALK39501@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:I describe Hi-C\, a novel technology for probing the three-dim
 ensional architecture of whole genomes. Developed together with collaborat
 ors at the Broad Institute and UMass Medical School\, Hi-C couples proximi
 ty-dependent DNA ligation and massively parallel sequencing. \n\nOur lab e
 mploys Hi-C to construct spatial proximity maps of the human genome. Using
  Hi-C\, it is possible to confirm the presence of chromosome territories a
 nd the spatial proximity of small\, gene-rich chromosomes.  Hi-C maps also
  reveal an additional level of genome organization that is characterized b
 y the spatial segregation of open and closed chromatin to form two genome-
 wide compartments.  At the megabase scale\, the conformation of chromatin 
 is consistent with a fractal globule\, a knot-free conformation that enabl
 es maximally dense packing while preserving the ability to easily fold and
  unfold any genomic locus. The fractal globule is distinct from the more c
 ommonly used globular equilibrium model. Our results demonstrate the power
  of Hi-C to map the dynamic conformations of whole genomes.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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