BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Amino acid patterns for protein folding - Kister\, A (Rutgers Univ
 ersity\, New Jersey\, USA)
DTSTART:20120904T103000Z
DTEND:20120904T105000Z
UID:TALK39520@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Understanding protein sequence-structure relationship is a key
  to solving many problems of molecular biology\, such as annotation of gen
 ome sequences\, protein structure prediction\, protein-protein interaction
 \, and protein evolution\, among others. These problems are convenient to 
 consider on the level of super-secondary structures\, which define arrange
 ment of strands and helices in 3D structures. In this presentation\, first
 \, the strict rule which describe how structure elements - beta-strands co
 me together into super-secondary structures of sandwich-like proteins will
  be presented. Then the main sequence regularities (a specific set of resi
 dues at particular positions)\, which dictate the folding of amino acid se
 quence will be described. Residues at certain positions constitute the cha
 racteristic residue pattern of specific super-secondary structures. The pa
 ttern can be viewed as an amino acid 'tag' that brands a sequence as havin
 g a particular super-secondary structure.\n\nReferences\n\nAlexander Kiste
 r and Israel Gelfand\, (2009) PNAS\, 106\, 18996-19000\nAlexander Kister  
 (2012) in "Protein super-secondary structures" Ed. A. Kister in "Methods i
 n Molecular Biology' series Humana Press (in press)  \n\n
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR