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SUMMARY:How to untie it-translocation of a knotted protein through a pore 
 - Szymczak\, P (University of Warsaw\, Poland)
DTSTART:20120904T105000Z
DTEND:20120904T111000Z
UID:TALK39521@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Proteins need to be unfolded when translocated through the por
 es in\nmitochondrial and other cellular membranes. Knotted proteins\, howe
 ver\,\nmight get stuck during this process since the diameter of the\npore
  is smaller than the size of maximally tightened knot. We report\nthe resu
 lt of computer simulations of knotted protein translocation\,\nwhich show 
 how the protein can avoid the topological traps and untie\nits knot during
  the translocation\n\n
LOCATION:Seminar Room 1\, Newton Institute
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