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SUMMARY:Conservation of complex knotting and slipknotting patterns in prot
 eins - Sulkowska \, J (University of California\, San Diego\, USA)
DTSTART:20120904T095000Z
DTEND:20120904T103000Z
UID:TALK39522@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:While analyzing all available protein structures for the prese
 nce of knots and slipknots we detected a strict conservation of complex kn
 otting patterns within and between several protein families despite their 
 large sequence divergence.  Since protein folding pathways leading to knot
 ted native protein structures are slower and less efficient than those lea
 ding to unknotted proteins with similar size and sequence\, the strict con
 servation of the knotting pattern indicates an important physiological rol
 e of knots and slipknots in these proteins.  Although little is known abou
 t the functional role of knots\, recent studies have demonstrated a protei
 n-stabilizing ability of knots and slipknots. Some of the conserved knotti
 ng patterns occur in proteins forming transmembrane channels where the sli
 pknot loop seems to strap together the transmembrane helices forming the c
 hannel. This is joint work with Ken Millett\, Andrzej Stasiak and Jose Onu
 chic.\n
LOCATION:Seminar Room 1\, Newton Institute
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