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SUMMARY:Knotted and unknotted proteins: a comparative study (*) - Michelet
 ti\, C (SISSA\, Trieste\, Italy)
DTSTART:20120904T081000Z
DTEND:20120904T085000Z
UID:TALK39524@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Knotted proteins\, because of their ability to fold reversibly
  in the same topologically entangled conformation\, are the object of an i
 ncreasing number of experimental and theoretical studies. The aim of the p
 resent investigation is to assess\, on the basis of presently available st
 ructural data\, the extent to which knotted proteins are isolated instance
 s in sequence or structure space\, and to use comparative schemes to under
 stand whether specific protein segments can be associated to the occurrenc
 e of a knot in the native state. A significant sequence homology is found 
 among a sizeable group of knotted and unknotted proteins. In this family\,
  knotted members occupy a primary sub-branch of the phylogenetic tree and 
 differ from unknotted ones only by additional loop segments. These "knot-p
 romoting" loops\, whose virtual bridging eliminates the knot\, are found i
 n various types of knotted proteins. Valuable insight into how knots form\
 , or are encoded\, in proteins could be obtained by targeting these region
 s in future computational or excision experiments. Results of recent relat
 ed simulations will be presented.\n\n(*) in collaboration with R. Potestio
  (MPI Mainz) and H. Orland (CEA Saclay)\; ref: R. Potestio et al. Plos Com
 p. Biol.  6\, e1000864 (2010)\, http://www.ploscompbiol.org/article/info:d
 oi/10.1371/journal.pcbi.1000864\n\n
LOCATION:Seminar Room 1\, Newton Institute
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