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SUMMARY:Co-operative roles for DNA supercoiling and nucleoid-associated pr
 oteins in the regulation of bacterial transcription - Dorman\, C (Trinity 
 College Dublin\, Ireland)
DTSTART:20120905T081000Z
DTEND:20120905T085000Z
UID:TALK39539@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:DNA supercoiling and nucleoid-associated proteins (NAPs) contr
 ibute to the regulation of transcription of many bacterial genes. The hori
 zontally-acquired Salmonella pathogenicity island (SPI) genes respond posi
 tively to DNA relaxation\, to the Fis and H-NS nucleoid-associated protein
 s and to the OmpR global regulatory protein. The ompR gene is autoregulate
 d and responds positively to DNA relaxation. Binding of the Fis and OmpR p
 roteins to DNA in the SPI-1 and SPI-2 islands and at the ompR gene promote
 r is differentially sensitive to the topological state of the DNA while H-
 NS binds regardless of the topological state of the DNA. These data illust
 rate the overlapping and complex nature of NAP and DNA topological contrib
 utions to transcription control in bacteria. They also show that these pro
 perties are shared by the core and the horizontally-acquired components of
  the bacterial genome.\n
LOCATION:Seminar Room 1\, Newton Institute
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