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SUMMARY:Superhelically Driven Structural Transitions in Genomic DNA - Theo
 retical Analyses\, Genomic Distributions and Roles in Regulation - Benham\
 , C (University of California\, Davis\, USA)
DTSTART:20120905T073000Z
DTEND:20120905T081000Z
UID:TALK39547@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:DNA is known to be a highly polymorphic molecule\, capable of 
 assuming several alternate conformations in addition to the standard Watso
 n-Crick B-form. These include states of strand separation\, left handed he
 lices\, cruciforms\, and three- and four-stranded structures. Although the
  B-form is its default conformation in vivo\, regions within genomic DNA c
 an be driven into alternate structures by the superhelicity imposed on the
  molecule by enzymatic activities and by transcription. This talk will pre
 sent theoretical analyzes of several types of transitions\, and of competi
 tions among them. The predicted genomic distributions of locations suscept
 ible to different types of superhelical transitions will be shown\, and th
 eir statistical significances will be assessed. Several situations will be
  described where transitions to alternate structures serve biological role
 s in either normal or pathological processes.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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