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SUMMARY:Denaturation transition of stretched DNA in the presence of DNA-bi
 nding ligands - Hanke\, A (University of Texas at Brownsville\, USA)
DTSTART:20120905T144000Z
DTEND:20120905T150000Z
UID:TALK39548@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Stretching experiments on DNA in the presence of DNA binding l
 igands have been shown to reveal insight into biological processes of DNA-
 ligand binding. We generalize the Poland-Scheraga model to consider DNA de
 naturation in the presence of an external stretching force and DNA-binding
  ligands which bind to double-stranded DNA by intercalating between two ad
 jacent base pairs. We obtain the phase diagram of DNA denaturation as a fu
 nction of temperature\, stretching force\, and the chemical potential of t
 he DNA-binding ligand. Force-extension relations are compared with recent 
 DNA stretching experiments in the presence of DNA intercalating ethidium a
 nd ruthenium complexes.\n
LOCATION:Seminar Room 1\, Newton Institute
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