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SUMMARY:A generic non-specific mechanism for the clustering of DNA and chr
 omosome binding proteins - Brackley\, C (University of Edinburgh)
DTSTART:20120906T131000Z
DTEND:20120906T135000Z
UID:TALK39564@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:In this talk I will present a generic mechanism which leads to
  the clustering of DNA-binding proteins\, on either prokaryotic DNA or euk
 aryotic chromatin. The clustering is driven by DNA-mediated interactions\,
  and remarkably\, does not require any affinity between the proteins\, whi
 ch we assume interact purely by steric repulsion. On naked DNA\, small pro
 teins cluster to form rows\, whereas larger\, histone-like proteins\, form
  more disordered aggregates. On flexible fibres such as chromatin\, the cl
 ustering leads to the formation of quasi-spherical foci. \n\nAdditionally 
 I will present results from a simulation of an ensemble of Pol II polymera
 ses and of p65 proteins (a well-characterised transcription factor) intera
 cting with chromosomes 5\, 8\, 14 and 17. These interactions lead to the f
 ormation of foci\, or factories\, where active regions in the DNA come tog
 ether. The statistics of the contacts compare favourably with 3C data on c
 ontacts made by SAMD4 on chromosome 14 and EXT1 on chromosome 8. \n\n
LOCATION:Seminar Room 1\, Newton Institute
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