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SUMMARY:Avian pathogenic E. coli (APEC): hidden genetic diversity in an ec
 onomical important poultry pathogen - Professor Lothar Wieler\, Department
  of Veterinary Medicine\, Freie Universität\, Berlin
DTSTART:20120912T153000Z
DTEND:20120912T163000Z
UID:TALK39662@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Avian pathogenic E. coli (APEC) are an important cause for los
 ses in poultry industry\, mainly affecting laying chickens. Although the p
 athogenesis of APEC has been investigated since two decades\, neither tran
 smission pathways nor key steps of pathogenicity are unravelled\, and find
 ings are contrasting each other. The talk will highlight recent findings f
 rom infection studies utilizing mutagenesis\, and discusses these in the c
 ontext of phylogenetic analyses of next-generation based whole genome sequ
 encing. Our cumulative data reveal that APEC is a highly divers pathotype\
 , that did not only develop on multiple occasions\, but also by the uptake
  of different virulence-associated factors. Thus\, the same avian disease 
 is caused by different APEC via distinct mechanisms. These findings are hi
 ghly important for a rational design of strategies to control a key animal
  disease.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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