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SUMMARY:Polyrotaxanes and Supramolecular Catalysis - Professor Akira Harad
 a\, Osaka University\, Japan
DTSTART:20121024T133000Z
DTEND:20121024T143000Z
UID:TALK39716@talks.cam.ac.uk
CONTACT:Sian Bunnage
DESCRIPTION:Polyrotaxanes in which many cyclodextrins are entrapped along 
 a polymer chain have been prepared. Molecular tubes have been prepared by 
 binding neighboring cyclodextrins with short biding reagents and then remo
 ving a polymer chain by cleaving stopper groups of the polyrotaxane. Artif
 icial polymerases with a molecular clamp were designed and prepared. Cyclo
 dextrins were found to initiate ring opening polymerization of some lacton
 es with high selectivity. Monomers were found to be inserted between cyclo
 dextrins and the growing chain. Cyclodextrins dimers were found to be much
  better catalysts for the ring opening polymerization. One of the cyclodex
 trins plays an important role as a molecular clamp as shown in DNA polymer
 ases in nature.
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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