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SUMMARY:Insights into regulatory genetic variation involving the human MHC
  - Dr Julian C Knight\, University of Oxford
DTSTART:20121017T113000Z
DTEND:20121017T123000Z
UID:TALK39763@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:The human Major Histocompatibility Complex (MHC) on chromosome
  6p21 is a remarkable region of the genome\, showing extraordinary genetic
  diversity and genetic associations with disease. \n\nIn my talk I will de
 scribe how functional genomic approaches may be used to resolve regulatory
  variants and provide new insights into the relationship between genetic v
 ariation and disease susceptibility.   I will discuss allele-specific anal
 ysis of specific loci and global approaches using a custom MHC array to in
 terrogate extended MHC haplotypes implicated in autoimmune disease.   \n\n
 I will also present data based on expression quantitative trait mapping in
  primary peripheral blood leukocytes which has defined trans associations 
 involving the MHC\, together with resolution of context specific expressio
 n associated variants for specific MHC genes.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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