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SUMMARY:Hepcidin\, immunity and global health - Dr Alexander Hal Drakesmit
 h\, University of Oxford
DTSTART:20121114T123000Z
DTEND:20121114T133000Z
UID:TALK39767@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Iron lies at the center of a battle for nutritional resource b
 etween higher organisms and their microbial pathogens. The iron status of 
 the human host affects the pathogenicity of numerous infections including 
 malaria\, HIV-1\, and tuberculosis. \n\nHepcidin\, an antimicrobial-like p
 eptide hormone\, has emerged as the master regulator of iron metabolism. H
 epcidin controls the absorption of dietary iron and the distribution of ir
 on among cell types in the body\, and its synthesis is regulated by both i
 ron and innate immunity. \n\nWe describe how hepcidin integrates signals f
 rom diverse physiological inputs\, forming a key molecular link between ir
 on trafficking and response to infection. Manipulation of hepcidin constit
 utes a new method for controlling immunity.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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