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SUMMARY:Using super-resolution microscopy to watch immune cells kill - Pro
 fessor Dan Davis\, Imperial College London
DTSTART:20121121T123000Z
DTEND:20121121T133000Z
UID:TALK39769@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Cell-contact dependent regulation of immune cell responses pla
 ys a vital role in balancing the need for rapid and efficient responses to
  a wide variety of pathological challenges\, while at the same time mainta
 ining self-tolerance. Over the last decade\, much research has studied how
  immune cell interactions are often accompanied by the segregation of prot
 eins into micrometer- and submicrometer-scale domains at an immune synapse
 . \n\nThe emerging new paradigm is that interactions between immune cell r
 eceptors\, kinases and adaptors are at least in part controlled by transie
 nt interactions between supramolecular assemblies. This is a significantly
  different concept from a linear cascade of individual protein-protein int
 eractions depicted in textbook diagrams of immune receptor signaling pathw
 ays. \n\nHere\, I will present new data using high- and super-resolution i
 maging techniques that reveal novel insights into molecular recognition by
  human Natural Killer cells and how specific effector functions are realiz
 ed. Our data reveal\, for example\, that remodelling of the cortical actin
  mesh occurs at the central region of the NK cell immune synapse during a 
 cytolytic response. This is likely to occur for other types of cell secret
 ion and emphasises the importance of emerging super-resolution imaging tec
 hnology for revealing new biology.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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