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SUMMARY:Lesson from the skin: the Aryl hydrocarbon Receptor (AhR) as an in
 flammatory brake in psoriasis - Dr Paola Di Meglio\, NIMR\, Mill Hill\, Lo
 ndon
DTSTART:20121128T123000Z
DTEND:20121128T133000Z
UID:TALK39770@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Psoriasis is a chronic inflammatory skin disease resulting fro
 m the interaction of genetic and environmental factors. \n\nThe pathogenic
  cross-talk between innate and adaptive cells underpins a dysregulated imm
 une response leading to aberrant epidermal proliferation. The Aryl hydroca
 rbon Receptor (AhR) is a ligand-dependent transcription factor that has be
 en shown to be involved in maintaining homeostasis at other barrier organs
  such as the gut. AhR is expressed in several skin cell types which\, by b
 eing in constant contact with the environment\, are exposed to potential e
 xogenous and endogenous AhR agonists. Thus\, AhR signaling may be importan
 t in psoriasis pathogenesis. \n\nTo investigate this potential role\, our 
 research uses a dual approach\, combining a mouse model of psoriasis-like 
 skin disease with the analysis of clinical skin samples from psoriasis pat
 ients. Our findings suggest that AhR has a critical role in modulating ski
 n immune responses and support further investigations to dissect the role 
 of AhR in the pathogenesis of psoriasis.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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