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SUMMARY:Coding with Dendrites - Panayiota Poirazi
DTSTART:20121106T160000Z
DTEND:20121106T170000Z
UID:TALK39776@talks.cam.ac.uk
CONTACT:Balazs B Ujfalussy
DESCRIPTION:The goal of this presentation is to provide a set of predictio
 ns generated by biophysical and/or abstract mathematical models regarding 
 the role of dendrites in information coding across three different brain r
 egions: the hippocampus\, the prefrontal cortex and the amygdala. Towards 
 this goal I will present modelling studies–along with supporting experim
 ental evidence-that investigate how dendrites may be used to facilitate th
 e coding of both spatial and temporal information at the single cell\, the
  microcircuit and the neuronal network level. I will first discuss how the
  dendrites of individual CA1 pyramidal neurons may allow a single cell to 
 discriminate between familiar versus novel memories and propagate this inf
 ormation to down stream cells [1]. I will then discuss how these dendritic
  nonlinearities may enable stimulus specificity in individual PFC pyramida
 l neurons during working memory [2] and underlie the emergence of sustaine
 d activity at the single cell and the microcircuit level [2\,3]. Finally\,
  I will present findings from our ongoing work regarding the role of dendr
 ites in shaping the formation of fear memory engrams in the amygdala [4].\
 n\n# Pissadaki\, E.K.\, Sidiropoulou K.\, Reczko M.\, and Poirazi\, P. “
 Encoding of spatio-temporal input characteristics by a single CA1 pyramida
 l neuron model” PLoS Comp. Biology\, 2010 Dec\;6(12): e1001038.\n# Sidir
 opoulou\, K. and Poirazi\, P. “Predictive features of persistent activit
 y emergence in regular spiking and intrinsic bursting model neurons” (PL
 oS Comp. Biology\, 2012 April\; 8(4): e1002489)\n# Papoutsi\, A.\, Sidirop
 oulou\, K.\, and Poirazi\, P. “Temporal Dynamics Predict State Transitio
 ns in a Prefrontal Cortex Microcircuit Model.” (submitted) \n# Kastelaki
 s G\, Sidropoulou K and Poirazi P “Modeling the fear memory trace”\, H
 ellenic Society for Neuroscience Annual Meeting\, October\, 2010.
LOCATION:CBL Meeting Room (BE4-38\, Dept. of Engineering)
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