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SUMMARY:The microvasculature - an early marker/driver of CVD risk across t
 he life-course - Professor Geraldine Clough.  University of Southampton.  
DTSTART:20130207T160000Z
DTEND:20130207T170000Z
UID:TALK40173@talks.cam.ac.uk
CONTACT:Annabel Griffiths
DESCRIPTION:While CVD risk factors are well known to enhance the developme
 nt of atherosclerotic lesions in large arteries\, there is now compelling 
 evidence that the structure and function of the microvasculature (arteriol
 es\, capillaries and venules ~150 μm or less in diameter) that reside wit
 hin the tissue parenchyma\, are also profoundly altered by CVD risk factor
 s. Obesity\, hypertension and impaired insulin-mediated glucose disposal a
 re all associated with an abnormal microvascular endothelium-dependent vas
 odilator response\, capillary recruitment\, and a reduced capillary densit
 y and network architecture. Furthermore\, there is growing evidence for th
 e negative impact of the maternal environment on the long term CV health o
 f her child and that mal-adaptations in the offspring peripheral vascular 
 structure and function during development may represent an important and a
 dditional risk determinant in the susceptibility to the development of car
 dio-metabolic disease in adult life. Study of the microcirculation offers 
 an important tool in the early identification of vascular dysfunction\, in
  disease risk stratification\, and in the evaluation of the impact of modi
 fiable (lifestyle and environmental) risk factors and efficacy of interven
 tion.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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