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SUMMARY:Multi-strain transmission dynamics of Johne's disease in commercia
 l dairy farms - Dr Rebecca Mitchell\, Cornell University
DTSTART:20121114T163000Z
DTEND:20121114T173000Z
UID:TALK40199@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Mycobacterium avium subspecies paratuberculosis (MAP) is a g
 astrointestinal pathogen of ruminants worldwide.  MAP is found in the maj
 ority of dairy cattle herds in both the US and Europe where it both costs 
 farmers in decreased production\, and is an animal welfare concern for cli
 nical animals.  The survival of this bacteria in processed dairy product
 s and potential link to Crohn's disease also create a potential food safet
 y concern.\n\nIn this talk I will present our initial models of MAP tran
 smission in closed US dairy farms\, as well as developments to these model
 s based on current longitudinal field data and experimental infections. Th
 rough the Regional Dairy Quality Management Alliance study\, we have longi
 tudinal field data from three northeastern US dairy farms for more than 6 
 years.  In addition to sampling animals semi-annually on the farm\, tissu
 e samples collected at slaughter have proven essential to understanding tr
 ue within-herd prevalence and infection progression within hosts.  Short 
 sequence repeat typing on all positive animals from a single farm has addi
 tionally allowed examination of questions of vertical transmission and adu
 lt infection.  Co-infections with multiple MAP strains may prove importan
 t to determining individual animal progression pathways. By combining our 
 field data with our modeling efforts\, we hope to address this real world 
 problem and improve our understanding of the true impact of intervention s
 trategies.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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