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SUMMARY:Lympho-epithelial cross talk in the gut - Professor Claudio Nicole
 tti\, Gut Health and Food Safety\, Institute of Food Research
DTSTART:20130424T151500Z
DTEND:20130424T161500Z
UID:TALK40200@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Under “steady state” conditions intestinal epithelial cell
 s (IECs) secrete anti inflammatory cytokines to maintain the correct intes
 tinal homeostasis. The introduction of “danger” signals represented by
  pathogenic bacteria rapidly triggers a series of events aimed at initiati
 ng inflammatory immune responses and to prevent or contain invasion and el
 iminate the pathogen. Of particular note\, we have observed that in respon
 se to pathogen exposure the intestinal epithelium rapidly recruits DCs to 
 the intestinal epithelium resulting in their migration into the lumen. We 
 have also observed bacteria-induced cytokine-mediated up-regulation of M c
 ell transport within the specialized follicle associated epithelium of Pey
 er’s patch. These rapid responses are indicative of the coordinated and 
 concerted action of IEC and DCs. Furthermore\, we have recently observed t
 hat the interplay between IEC-derived and DC-derived cytokines is critical
  for maintaining intestinal immune homeostasis. In particular our attentio
 n has been focused on the role played by the reciprocal control and regula
 tion taking place between epithelium-derived thymic stromal lymphopoietin 
 (TSLP) and DC-derived IL-12. Alteration of this regulatory pathway has a p
 rofound influence on the generation of immune responses.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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