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SUMMARY:A matter of size: molecular basis and diagnostic approach to inher
 ited macrothrombocytopenia - Dr Maria Elena Gelain\, Comparative Pathology
  and Veterinary Hygiene\, University of Padova
DTSTART:20121128T163000Z
DTEND:20121128T173000Z
UID:TALK40201@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Platelets are the first line of defence against bleeding secon
 dary to vascular injury and anomaly in their number or function may lead t
 o mucucutaneous bleeding.\nSimilarly to humans\, several inherited thrombo
 pathia and thrombocytopenia have been reported in animals. Each of these d
 isorders is characterized by different clinical signs that reflect differe
 nces in molecular basis and disease phenotype.\nHowever\, not all the inhe
 rited intrinsic platelets disorders cause haemorrhages. Asymptomatic inher
 ited macrothrombocytopenia is a well-recognized disorder in Cavalier King 
 Charles Spaniel (CKCS) and recently it has been recognized in other canine
  breeds\, such as Norfolk and Cairn Terriers. This disorder is not associa
 ted with abnormal bleeding but a misdiagnosis as inherited macrothrombocyt
 openia can lead to inappropriate diagnostic investigations and therapies. 
 This presentation will discuss the molecular basis of canine asymptomatic 
 inherited macrothrombocytopenia\, its clinical presentation and the useful
 ness of automated hematologic analyser and new platelet parameters in orde
 r to identify and further characterize this condition.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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