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SUMMARY:Next Generation Genome Engineering using CompoZr Zinc Finger Nucle
 ases - Gurpreet Balrey &amp\; Mark Skinner\, Sigma Life Sciences
DTSTART:20121010T153000Z
DTEND:20121010T163000Z
UID:TALK40203@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Zinc finger nucleases (ZFNs) are a class of engineered DNA-bin
 ding proteins that facilitate targeted editing of the genome by creating d
 ouble-strand breaks in DNA at user-specified locations. Double-strand brea
 ks are important for site-specific mutagenesis in that they stimulate the 
 cell’s natural DNA-repair processes\, namely homologous recombination an
 d Non-Homologous End Joining (NHEJ). Using well-established and robust pro
 tocols\, these cellular processes can be harnessed to generate precisely t
 argeted genomic edits resulting in cell lines\, including somatic cell lin
 es\, with targeted gene deletions (Knockouts)\, integrations\, or modifica
 tions. Sigma® Life Science has applied the revolutionary CompoZr® Zinc F
 inger Nuclease technology to create an unparalleled range of genetically m
 odified mammalian cell lines \, rat\, mouse and rat models and most recent
 ly engineered human inducible pluripotent stem cell lines (iPSCs) for use 
 in areas such as basic research\, target validation\, drug discovery and d
 rug development.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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