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SUMMARY:A histone tail:  Pre-messenger RNA splicing and the coordinated co
 ntrol of gene expression - Dr Tracy Johnson. UC San Diego.
DTSTART:20121116T100000Z
DTEND:20121116T110000Z
UID:TALK40254@talks.cam.ac.uk
CONTACT:Annabel Griffiths
DESCRIPTION:Pre-messenger RNA splicing\, the removal of noncoding intron s
 equences from RNA\, is a crucial and tightly regulated step in gene expres
 sion. This reaction is carried out by a highly-conserved\, dynamic ribonuc
 leoprotein complex\, the spliceosome. Although assembly of this macromolec
 ular machine onto a pre-messenger RNA can be observed in vitro as a bioche
 mically isolated reaction\, recent work from our lab has shown that splice
 osome assembly occurs co-transcriptionally\, while the nascent RNA is bein
 g synthesized\, which has important mechanistic consequences.  We demonstr
 ate that histone modification mediates co-transcriptional association of t
 he spliceosome onto RNA\, and the dynamic rearrangements required for accu
 rate splice site recognition are influenced by the state of the chromatin.
  Understanding these exquisitely coordinated molecular events has importan
 t biological implications\, as regulation of pre-mRNA splicing is crucial 
 for cellular response to environmental perturbations.
LOCATION:Bryan Matthews Seminar Room\, Physiology Building\, Downing Site
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