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SUMMARY:Phase-shifted gene-activity oscillations during embryo development
  - a real-time imaging approach. - Dr Alexander Aulehla from EMBL Heidelbe
 rg 
DTSTART:20121018T133000Z
DTEND:20121018T143000Z
UID:TALK40465@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:In our group\, we are focusing on the temporal aspect of embry
 onic development and thus on the role of embryonic clocks\, or oscillators
 . Oscillations in Wnt\, Fgf and Notch-signaling pathway activity (period ~
 2hours) have been identified during mesoderm patterning in vertebrate embr
 yos and are linked to the formation of pre-vertebrae\, or somites. Most st
 rikingly\, oscillations occur phase-shifted between neighbouring cells\, p
 roducing spatio-temporal activity patterns within the embryo. Using a comb
 ination of genetically engineered dynamic reporter mouse lines\, functiona
 l perturbations and quantitative in vivo measurements\, we currently addre
 ss the principles underlying synchronization.
LOCATION:Part II Room\, Department of Genetics
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