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SUMMARY:The impact of cohesin on the regulation of gene expression and the
  organization of chromatin - Matthias Merkenschlager\, Lymphocyte Developm
 ent Group\, MRC Clinical Sciences Centre\, Imperial College London
DTSTART:20130418T120000Z
DTEND:20130418T130000Z
UID:TALK40492@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Cohesin-mediated sister chromatid cohesion is essential for ch
 romosome segregation and post-replicative DNA repair. Growing evidence fro
 m human genetics and model organisms links cohesin to the formation of lon
 g-range chromosomal interactions and to the regulation of gene expression 
 in association with CTCF\, mediator\, or tissue-specific transcription fac
 tors. We have taken genetic approaches to determine the impact of cohesin 
 on developmentally regulated gene expression and the organization of chrom
 atin in non-dividing mammalian cells. Since gene dosage reductions in the 
 cohesin loading factor Nipbl are the leading cause of Cornelia de Lange sy
 ndrome\, we have also investigated the transcriptional and post-transcript
 ional regulation of Nipbl expression.
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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