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SUMMARY:Duplicating the Human genome: The Origin Recognition Complex et al
  - Bruce Stillman\, FAA\, FRS - Cold Spring Harbour Laboratory\, New York
DTSTART:20130620T120000Z
DTEND:20130620T130000Z
UID:TALK40494@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:The entire process of duplication of the cell’s genetic mate
 rial is started by the ATP-dependent Origin Recognition Complex (ORC) bind
 ing to chromosomes and then promoting the establishment of pre-Replicative
  Complexes (pre-RCs) at numerous sites within the genome. Following pre-RC
  assembly\, multiple protein kinases and other regulatory processes contro
 l the recruitment of many replication proteins that initiate DNA synthesis
 . In the process the pre-RCs are destroyed. Stillman will discuss the bioc
 hemical steps in assembly of pre-RCs and present data on how the process o
 f initiation of DNA replication is controlled by Cyclin-dependent protein 
 kinases (CDKs)\, the Dbf4-Cdc7 protein kinase (DDK) and cell proliferation
  regulators such as the retinoblastoma protein Rb. Inherited genetic effec
 ts in genes encoding pre-RC proteins such as ORC cause Meier-Gorlin Syndro
 me\, a disorder resulting in short stature and microcephaly. ORC mutations
  affect both DNA replication and centrosome duplication\, contributing to 
 the diverse phenotypes in such individuals.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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