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SUMMARY:HER2 and EGFR: Signalling mechanisms and next generation cancer th
 erapies - Yosef Yarden\, Weizmann Institute of Science\, Israel
DTSTART:20130718T120000Z
DTEND:20130718T130000Z
UID:TALK40495@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Tumor-specific combinations of oncogenic mutations often free 
 cancer cells from their reliance on growth factors. One important example 
 comprises the epidermal growth factor receptor (EGFR) and its kin\, HER2. 
 In tumours\, both EGFR and HER2 frequently display overexpression\, intern
 al deletions and point mutations. Accordingly\, monoclonal antibodies and 
 kinase inhibitors specific to these receptors have been approved for clini
 cal application. My lecture will introduce our efforts to develop novel ag
 ents able to intercept growth factor signalling in tumours. Examples inclu
 de aptamers\, antibody combinations and decoy receptors. Alongside\, my la
 boratory is interested in molecular mechanisms underlying the ability of E
 GFR and HER2 to enhance cell proliferation and promote invasive growth. I 
 will focus on a model that portrays growth factor signalling as a pulsatil
 e mechanism that eliminates noise and commits cells to consistent extracel
 lular ques. In addition\, I will describe several transcription-based mech
 anisms that explain the invasive behavior of HER2 and EGF-driven cancer ce
 lls.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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