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SUMMARY:Inflammation and Cancer: Reprogramming the immune microenvironment
  as an anti-cancer therapeutic strategy - Lisa M. Coussens. Department of 
 Cell &amp\; Developmental Biology\, Knight Cancer Institute\, Oregon Healt
 h &amp\; Sciences University
DTSTART:20130919T120000Z
DTEND:20130919T130000Z
UID:TALK40496@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:The concept that leukocytes are components of malignant tumors
  is not new\; however\, their functional involvement as promoting forces i
 n tumor progression has only recently been appreciated.  We are interested
  in understanding the molecular mechanisms that regulate leukocyte recruit
 ment into neoplastic tissue\, subsequent regulation those leukocytes exert
  on evolving cancer cells\, and how malignant cells in turn respond to cyt
 otoxic therapies.  By studying transgenic mouse models of skin\, lung\, br
 east and pancreas cancer development\, we have appreciated that adaptive l
 eukocytes differentially regulate myeloid cell recruitment\, activation\, 
 and behavior\, by organ-dependent mechanisms.  In turn\, selective myeloid
  cell types provide key survival factors to malignant cells\, foster angio
 genic programs and invariably blunt CD8+ T cell-mediated killing of tumor 
 cells.  Treatment of transgenic mice predisposed to these various cancer t
 ypes with agents that selectively block adaptive/myeloid-based programs re
 sults in slowing of primary tumor growth\, improved responses to chemother
 apeutic drugs\, and significantly diminished presence of metastatic diseas
 e.  To be presented will be recent insights into organ and tissue-specific
  regulation of epithelial cancer development by adaptive and innate immune
  cells\, and new studies evaluating how attenuating protumor properties of
  myeloid cells can be exploited to enhance therapeutic responses to cytoto
 xic therapy.\n\nLMC acknowledges generous support from the NIH / NCI\, the
  Department of Defense Era of Hope Scholar Expansion Award\, Susan G. Kome
 n Foundation\, and the Breast Cancer Research Foundation.\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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