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SUMMARY:Network biology of cancer - Andrea Califano (Columbia University\,
  New York)
DTSTART:20120928T093000Z
DTEND:20120928T103000Z
UID:TALK40523@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:This is advance notice of this seminar.  Dr Califano’s lab h
 ave been leaders in the development of biochemically validated genome-wide
  maps of transcriptional and post-transcriptional interaction in several h
 uman cell contexts\, including different cancer types and normal and tumou
 r-related stem cells.  The Califano lab integrates the development of anal
 ytical methodologies with high-throughput experimental assays for data gen
 eration and biological/biochemical validation.  In particular\, the lab ha
 ve developed the “master regulator” concept in human tumours and the 
 “bottleneck” hypothesis of master regulator function in glioma.  Recen
 t publications include:\n\n# Califano A\, Butte AJ\, Friend S\, Ideker T\,
  Schadt E. Leveraging models of cell regulation and GWAS data in integrati
 ve network-based association studies. Nat Genet. 2012 Jul 27\;44(8):841-7 
 \n# Sumazin P\, Yang XR\, Chiu HS\, Chung WJ\, Iyer A\, Llobet-Navas D\, e
 t al. An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regul
 ates Established Oncogenic Pathways in Glioblastoma. Cell. 2011\;147(2):37
 0-81. \n# Carro MS\, Lim WK\, Alvarez MJ\, Bollo RJ\, Zhao X\, Snyder EY\,
  Sulman EP\, Anne SL\, Doetsch F\, Colman H\, Lasorella A\, Aldape K\, Cal
 ifano A\, Iavarone A. The transcriptional network for mesenchymal transfor
 mation of brain tumours\, Nature. 2010 Jan 21\;463(7279):318-25. PMID: 200
 32975 \n\nDr Califano is a clear speaker\, and his talks are generally acc
 essible to those who are not expert in the statistical and computational a
 spects of this field.  
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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