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SUMMARY:Riddle of the Sphinx: Sphingolipid glycosylation - a possible role
  in plant immunity? - Jenny Mortimer\, Dupree Lab (Department of Biochemis
 try)
DTSTART:20121012T120000Z
DTEND:20121012T123000Z
UID:TALK40554@talks.cam.ac.uk
CONTACT:24938
DESCRIPTION:The Arabidopsis Golgi-localised protein\, GONST1\, is a GDP-Ma
 nnose transporter that was thought to provide precursors for the synthesis
  of cell wall polysaccharides such as glucomannan. Using liposome assays\,
  we showed that GONST1 can transport all four plant GDP-linked monosacchar
 ide sugars: GDP-Man\, GDP-Glc\, GDP-L-Gal and GDP-Fuc. However\, gonst1 mu
 tants have no detectable alterations in cell wall polysaccharides synthesi
 zed from these precursors. In contrast\, we showed that glycosylinositolph
 osphoceramide (GIPC) sphingolipid headgroups contain mannose and that thes
 e decorations are decreased in gonst1 GIPCs. gonst1 plants have a dwarfed 
 phenotype\, and a constitutive hypersensitive response with elevated salic
 ylic acid. This suggests an unexpected role for GIPC sugar decorations in 
 sphingolipid function and plant defence signalling.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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