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SUMMARY:Mitochondria and the cytoskeleton – matters of life and death in
  the face of stress - Dr Campbell Gourlay\, University of Kent
DTSTART:20121010T140000Z
DTEND:20121010T150000Z
UID:TALK40757@talks.cam.ac.uk
CONTACT:Penny Peck
DESCRIPTION:Cell survival in the face of stress relies upon linking the pe
 rception of change to appropriate downstream responses. The actin cytoskel
 eton\, in addition to its better known role as a cellular scaffold\, is em
 erging as an important co-ordinator of stress perception and response. Of 
 particular note appears to be the conserved role that actin plays in regul
 ating mitochondrial function in response to a variety of stresses. This re
 lationship can be utilised to engage the mitochondria within newly discove
 red retrograde signalling pathways\, or to initiate apoptosis. Using the m
 odel eukaryote S. cerevisae we have identified new pathways that link the 
 health of both the actin cytoskeleton and the mitochondria to environmenta
 l responses that determine cell fate.
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, A
 ddenbrooke's Site
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