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SUMMARY:Development of the DNA Vaccine Against HIV/AIDS - Professor Mart U
 stav
DTSTART:20121030T181500Z
DTEND:20121030T193000Z
UID:TALK40809@talks.cam.ac.uk
CONTACT:James Scott-Brown
DESCRIPTION:Prof Ustav shall explain how study of the general functions of
  the papillomavirus proteins led to the development of the DNA plasmid bas
 ed expression vectors\, which were effectively used in vivo. In fact\, his
  group used papillomavirus protein E2 and respective binding sites in the 
 viral genome and engineered recombinant plasmid\, which has similar proper
 ties to papillomavirus genomes: a) to be maintained as multicopy nuclear e
 xtrachromosomal element in the nucleus of the transfected cells for extend
 en time and b) be transfered to the daughter cells in the similar fashion 
 like papillomavirus genomes. Addition of this papillomavirus genome functi
 on generated expression plasmid which produced the produt of interest — 
 HIV1 antigens\, at the very much higher level in comparison to conventiona
 l vectors and expression is maintained for much longer time in the targete
 d tissue. Application of such DNA vaccine into HIV1 positive treatment nai
 ve patients resulted in induction of anti-HIV specific T-cell immune respo
 nse\, reduction of the viral load up to one order of magnitude and increas
 e in CD4+ cell counts by 20% as shown in phase II clinical study. 
LOCATION:Winstanley Lecture Theatre
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