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SUMMARY:Exploring the Human Connectome: The Rich and Famous - Martijn van 
 den Heuvel\, University Medical Center Utrecht\, Netherlands
DTSTART:20121030T110000Z
DTEND:20121030T120000Z
UID:TALK40889@talks.cam.ac.uk
CONTACT:Mikail Rubinov
DESCRIPTION:Within our brain\, billions of neurons continuously interact t
 hrough trillions of connections\, together forming one integrative system\
 , the human connectome. Healthy brain function depends on efficient neuron
 al signaling within this complex web of structural and functional interact
 ions and for long distance communication and global integration of informa
 tion in particular\, the formation of highly connected nodes may be of piv
 otal importance. \n\nBesides being individually ‘rich’ in connectivity
 \, recent studies have suggested that these putative ‘brain hubs’ may 
 show dense interconnectivity\, suggesting the formation of a topological c
 entral collective that may act as a global attractor and integrator of neu
 ronal information: the brain’s rich club. \n\nIn my talk I will highligh
 t recent advances of connectome research in the mammalian brain\, discussi
 ng the underlying thoughts that brain function may result not solely from 
 single brain areas but rather emerges from interaction between brain regio
 ns\, how the underlying structural and functional topology of the brain’
 s network may play an important role in brain functioning and perhaps cogn
 itive performance\, and how\, conversely\, affected brain connectivity may
  potentially underly brain disfunctioning as seen in several psychiatric a
 nd neurological brain disorders\, such as schizophrenia\, autism\, Alzheim
 er’s disease and ALS. In addition\, I will discuss some of the recent id
 eas of the rich club to form a communication skeleton\, a central system t
 hat may\, offsetting its high cost\, aid the efficient routing of long-dis
 tance neuronal signaling and thus may act as a central high-cost\, high-ca
 pacity backbone for global brain communication.\n
LOCATION:MRC CBU lecture theatre\, 15 Chaucer Road
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