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SUMMARY:Food for thought: nutrients and neural stem cells in Drosophila - 
 Dr Alex Gould. MRC National Institute for Medical Research\, London.
DTSTART:20130214T160000Z
DTEND:20130214T170000Z
UID:TALK40890@talks.cam.ac.uk
CONTACT:Annabel Griffiths
DESCRIPTION:Moderate nutrient deprivation in animals is often compatible w
 ith development\, albeit into an undersized adult. One important survival 
 strategy here is to spare the growth of certain critical organs\, such as 
 the CNS\, at the expense of others. For example\, in humans\, fetal nutrie
 nt restriction can result in asymmetric intrauterine growth restriction (I
 UGR)\, characterised by undersized neonates with relatively large brains. 
 We have been exploring the molecular mechanisms underlying this type of br
 ain sparing in the context of the growing CNS of Drosophila. This work has
  identified a highly modified Insulin/Tor signalling network that permits 
 neural stem cells to grow and divide at the normal rate under conditions o
 f nutrient restriction that are severe enough to shut down all net growth 
 of the body. We also find that optimal CNS growth during this type of nutr
 ient stress requires neural stem cells to be metabolically coupled to thei
 r glial-cell niche. The possible relevance of these findings to mammalian 
 brain sparing and\, more generally\, to the mechanisms by which nutrients 
 regulate the relative growth of different tissues will be discussed.\n\nSe
 lected Publications (last five years)\nSteinhauser\, M.L\, Bailey\, A.P\, 
 Senyo\, S.E\, Guillermier\, C\, Perlstein\, T.S\, Gould\, A.P\, Lee\, R.T 
 and Lechene\, C.P. (2012). Multi-isotope imaging mass spectrometry quantif
 ies stem cell division and metabolism.\nNature 481\, 516-519\nCheng\, L.\,
  Bailey\, A.\, Leevers\, S.\, Ragan\, T.\, Driscoll\, P. and Gould\, A.P. 
 (2011). Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Res
 triction in Drosophila.\nCell 146\, 435-447.\nSousa-Nunes\, R\, Yee\, LL a
 nd Gould\, A.P. (2011). Fat cells reactivate quiescent neuroblasts via TOR
  and glial insulin relays in Drosophila.\nNature 471\, 508-512.\nMaurange\
 , C.\, Cheng\, L.\, and Gould\, A.P. (2008). Temporal transcription factor
 s and their targets schedule the end of neural proliferation in Drosophila
 .\nCell 133\, 891-902.\nMiguel-Aliaga\, I.\, Thor\, S.\, and Gould\, A.P. 
 (2008). Postmitotic specification of Drosophila insulinergic neurons from 
 pioneer neurons.\nPLoS Biology 6\, e58.\nGutierrez\, E.\, Wiggins\, D.\, F
 ielding\, B. and Gould\, A.P. (2007) Specialized hepatocyte-like cells reg
 ulate Drosophila lipid metabolism.\nNature 445\, 275-280.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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