BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Society of Chemical Industry (SCI) College of Scholar Presentation s &\; Networking Event - Prof Alan Heaton DTSTART:20121031T163000Z DTEND:20121031T193000Z UID:TALK40959@talks.cam.ac.uk CONTACT:John O'Toole DESCRIPTION:SCI is proud to present three bright young members of its Coll ege of Scholars programme. Join us for tea and biscuits before the present ation and network afterward while enjoying drinks and nibbles. \n\n*Aditi Borka - University of Cambridge (Michele Vendruscolo Group)*\n_Choreograph y of RNA_ - The functions of macromolecules in the cell depend on their st ructure and dynamics. Consequently there is great interest in the developm ent of experimental and computational techniques to understand these aspec ts at the atomic level. I will outline a novel approach to study the in-vi tro dynamical properties of RNA at atomic resolution. This method harnesse s molecular dynamics simulations with restrains derived from NMR Residual Dipolar Couplings (RDCs) on different RNA molecules. The conformational en sembles generated represent the range of structures that RNA populates in the native state. The RNA molecules that I am considering cover various as pects of RNA behaviour\, including RNA-protein interactions\, RNA-DNA inte ractions and RNA catalysis\, and thus will help understand the role of dyn amics in these processes. \n\n*James Frost - University of Cambridge (Prof Steve Ley Group)* \n_Total synthesis of anti-cancer natural products call ipeltoside A\, B and C_ – A highly convergent route has been developed t hat has allowed access to this family of natural products. This has been a chieved by a) use of a high yielding approach to the pyran core\; b) forma tion of the entire vinyl iodide containing di-ene-yne fragment in a stereo specific manner and c) union of these fragments via a diastereoselective a lkenylmetal addition. This was followed by macrolactonisation to provide t he common callipeltoside aglycon. Rapid construction of each sugar unit fr om a single commercially available starting material and subsequent attach ment to the aglycon provided the entire family of the callipeltosides.\n\n *James Womack - University of Bristol (Prof Fred Manby Group)*\n_A new met hod of approximating many-electron integrals in explicitly-correlated meth ods_ - Chemistry is fundamentally about understanding the behaviour of ele ctrons. Each electron interacts repulsively with every other electron in a system\, and their motion is therefore said to be correlated. Accurate el ectronic structure calculations on chemical systems require some treatment of these correlations. Explicitly-correlated methods allow for efficient treatment of electron correlation\, but also introduce numerous and comple x many-electron integrals. For explicitly-correlated methods to be practic ally implemented\, these integrals must be approximated. In this talk\, I will outline a new method of approximating these integrals and why this me thod may present an improvement on the current state of the art.the studie s towards the total synthesis and structural determination of these three natural products. The overall retrosynthetic strategy involves a late-stag e olefination procedure to attach the trienoic acid sidechain to the tricy clic core thus developing a convergent strategy for the total synthesis wh ich should allow access to a variety of analogues for further biological t esting.\n\n*This event is co-hosted by Cambridge University ChemSoc.*\n\nF or more information\, please visit the SCI website *www.soci.org* LOCATION:Pfizer Lecture Theatre\, Department of Chemistry\, Lensfield Road \, Cambridge END:VEVENT END:VCALENDAR