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PRODID:-//Talks.cam//talks.cam.ac.uk//
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BEGIN:VEVENT
SUMMARY:Effects of G-quadruplexes on transcription - Dario Beraldi\, Balas
 ubramanian Group
DTSTART:20121026T150000Z
DTEND:20121026T160000Z
UID:TALK41164@talks.cam.ac.uk
CONTACT:Nicholas Shannon
DESCRIPTION:DNA sequences rich in guanine can acquire a four-stranded conf
 ormation known as G-quadruplex which can be more stable than the double-he
 lix. The possibility of inducing G-quadruplex structures has suggested the
 m as possible drug targets to control gene expression. We have treated hum
 an cells (fibroblasts\, MRC-5 SV40) with pyridostatin\, a compound capable
  of stabilizing G-quadruplexes\, and compared their transcriptome with con
 trol cells by means of RNA-Seq. \n\nIn this talk we will show some analyse
 s aimed at characterizing the effect of pyridistatin on gene expression an
 d splicing in relation to the putative G-quadruplex sequences in the human
  genome.
LOCATION:215
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