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SUMMARY:Toward reliable characterization of functional homogeneity in the 
 functional connectome - Xi-Nian Zuo\, Research Professor\, Institute of Ps
 ychology\, Chinese Academy of Sciences\, Beijing
DTSTART:20121106T110000Z
DTEND:20121106T120000Z
UID:TALK41233@talks.cam.ac.uk
CONTACT:Mikail Rubinov
DESCRIPTION:While researchers have extensively characterized functional co
 nnectivity between brain regions\, the characterization of functional homo
 geneity within a region of the brain connectome is in early stages of deve
 lopment. Several functional homogeneity measures were proposed previously\
 , among which regional homogeneity (ReHo) was most widely used as a measur
 e to characterize functional homogeneity of resting state fMRI (R-fMRI) si
 gnals within a small region. Despite a burgeoning literature on ReHo in th
 e field of neuroimaging brain disorders\, its test-retest (TRT) reliabilit
 y remains unestablished. Using two sets of public R-fMRI TRT data\, we sys
 tematically evaluated the ReHo's TRT reliability and further investigated 
 the various factors influencing its reliability and found: 1) nuisance (he
 ad motion\, white matter\, cerebrospinal fluid) correction of R-fMRI times
 eries can significantly improve the TRT reliability of ReHo while addition
 al removal of global brain signal reduces its reliability\, 2) Spatial smo
 othing of R-fMRI timeseries artificially enhances ReHo intensity and influ
 ences its reliability\, 3) surface-based R-fMRI computation largely improv
 es the TRT reliability of ReHo\, 4) a scan duration of 5 minutes can achie
 ve reliable estimates of ReHo\, and 5) fast sampling rates of R-fMRI drama
 tically increase the reliability of ReHo. Inspired by these findings and s
 eeking a highly reliable approach to exploratory analysis of the human fun
 ctional connectome\, we established an R-fMRI pipeline to conduct ReHo com
 putations in both 3-dimensions (volume) and 2-dimensions (surface).\n
LOCATION:BCNI seminar room\, Sir William Hardy Building\, Downing Site
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