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SUMMARY:Multiparametric MRI of the vasculature: applications to therapy mo
 nitoring of gliomas - Chantal Remy\, Grenoble Institute of Neurosciences\,
  France
DTSTART:20121212T163000Z
DTEND:20121212T173000Z
UID:TALK41415@talks.cam.ac.uk
CONTACT:Laura Blackburn
DESCRIPTION:Microvascular alterations have been observed in numerous brain
  pathologies\, including brain\ntumours\, brain ischemia\, brain trauma an
 d neurodegenerative diseases. Vascular density\,\nmorphology\, permeabilit
 y and reactivity as well as blood volume\, flow and oxygenation may\nbe af
 fected. Characterization of these modifications may be of clinical interes
 t for diagnosis\,\nprognosis\, treatment planning\, and therapeutic follow
 -up. From a more fundamental point of\nview\, this characterization may be
  useful for improving our understanding of the mechanisms\nunderlying the 
 evolution of these pathologies or the action of new therapies. The team\nh
 as developed novel MRI methods to map the characteristic parameters of the
  cerebral\nmicrovasculature: blood volume\, vessel diameters\, and oxygena
 tion. These methods were\nvalidated on healthy animal and bearing intracer
 ebral gliomas. An integration of these methods\nwith diffusion imaging\, b
 lood flow and permeability to two different contrast agents offer a\nmulti
 parametric imaging protocol of the vasculature (duration 1h15min). We eval
 uated the\ninterest of each of these parameters as indicators of therapeut
 ic effect on glioma models in rats\nin the case of an antiangiogenic thera
 py (sorafenib) and an innovative method of radiotherapy\,\nsynchrotron mic
 robeam radiation. Multiparametric MRI appears as an imaging modality with 
 a\nhigh potential for preclinical evaluation of new therapeutic strategies
  and clinical as an indicator\nof therapeutic effect. The clinical transfe
 r of these methods is in progress.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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