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SUMMARY:Self-assembly of icosahedral viral capsids: the combinatorial anal
 ysis approach - Kerner\, R (Universit Pierre et Marie Curie - Paris VI)
DTSTART:20121115T113000Z
DTEND:20121115T123000Z
UID:TALK41518@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:An analysis of all possible icosahedral viral capsids is propo
 sed. It takes into account the diversity of coat proteins and their positi
 oning in elementary pentagonal and hexagonal configurations\, leading to d
 efinite capsid size. We show that the self-organization of observed capsid
 s during their production implies a definite composition and configuration
  of elementary building blocks. The exact number of different protein dime
 rs is related to the size of a given capsid\, labeled by its $T$-number. S
 imple rules determining these numbers for each value of $T$ are deduced an
 d certain consequences concerning the probabilities of mutations and evolu
 tion of capsid viruses are discussed.\n
LOCATION:Seminar Room 1\, Newton Institute
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