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SUMMARY:IRF5 in regulation of macrophage inflammatory gene programme - Dr 
 Irina Udalova\, Kennedy Institute of Rheumatology\, University of Oxford
DTSTART:20130123T123000Z
DTEND:20130123T133000Z
UID:TALK41789@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Recently\, we have discovered that transcription factor IRF5 p
 lays a direct role in establishing a pro-inflammatory phenotype of macroph
 ages. Macrophages are immune cells that are essential for the initiation a
 nd resolution of pathogen- or tissue damage-induced inflammation. They dem
 onstrate remarkable plasticity that allows them to efficiently respond to 
 environmental signals and change their phenotype and physiology in respons
 e to cytokines and microbial signals. \n\nWe have demonstrated that IRF5 d
 irects transcriptional activation of the majority of pro-inflammatory cyto
 kines\, chemokines and co-stimulatory molecules and begun to dissect the m
 olecular mechanisms of IRF5 directed gene regulation. Moreover\, genetic p
 olymorphisms in the IRF5 gene\, leading to increased IRF5 mRNA expression\
 , are associated with a number of autoimmune diseases\, including rheumato
 id arthritis\, systemic lupus erythematosus\, Sjogren’s syndrome\, multi
 ple sclerosis and inflammatory bowel disease. \n\nOur current understandin
 g of the molecular events in immune cells responsible for IRF5 pathogenic 
 function during the inflammatory response will be discussed. \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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