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SUMMARY:'Dendritic cells and pluripotency: Unlikely allies in the pursuit 
 of immunotherapy' - Dr Paul Fairchild\, Dunn School of Pathology\, Univers
 ity of Oxford
DTSTART:20130213T123000Z
DTEND:20130213T133000Z
UID:TALK41793@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Although the dramatic increase in life expectancy we have witn
 essed over the past century is arguably one of medicine’s greatest succe
 sses\, it is also responsible for the rising incidence of chronic and dege
 nerative diseases throughout the developed world. \n\nThe properties of pl
 uripotent stem cells (PSC) offer an attractive strategy to address some of
  the health-care needs that the current trend in aging will inevitably pos
 e. Nevertheless\, their use in cell replacement therapy faces many challen
 ges\, the greatest of which is undoubtedly their immunogenicity\, which th
 reatens to undermine the success of regenerative medicine in the future. \
 n\nThe first half of this seminar will\, therefore\, investigate the exten
 t of immune privilege displayed by tissues differentiated from PSC and the
  feasibility of tapping into such properties to secure their long-term sur
 vival through the induction of transplantation tolerance. Although the rou
 tine application of PSC within a clinical setting still remains a distant 
 goal\, their use as a novel source of dendritic cells whose administration
  to recipients may affect a lasting immunological legacy long after their 
 demise\, provides a more realistic prospect. \n\nThe second half of this s
 eminar will\, therefore\, discuss the advantages of using PSC as a source 
 of DC for immunotherapy and the unique properties that make them attractiv
 e candidates for downstream clinical applications.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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