BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:How to maintain a stable genome: A Passenger Perspective. - Dr Sus
 anne Lens from University Medical Centre Utrecht
DTSTART:20130221T143000Z
DTEND:20130221T153000Z
UID:TALK41990@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Chromosomal instability (CIN) and the resultant aneuploid geno
 mic state is a hallmark of cancer. Whether CIN is cause or consequence of 
 cancer has for long been a matter of debate\, but evidence is accumulating
  that it can contribute to tumor progression. Chromosome instability refer
 s to a high rate of chromosome segregation errors during cell division and
  my lab aims to understand why cancer cells become chromosomally instable.
  In order to do so it is essential to first comprehend the molecular pathw
 ays that ensure error-free chromosome segregation. An essential protein co
 mplex required for faithful chromosome segregation is the Chromosomal Pass
 enger Complex (CPC)\, consisting of Aurora B kinase\, INCENP\, survivin an
 d borealin. The CPC has a dynamic localization pattern in the dividing cel
 l being present on the inner centromere in (pro)metaphase while moving to 
 the central spindle in anaphase and midbody in telophase. Given its typica
 l localization pattern it is not surprising the CPC regulates both nuclear
  and cytoplasmic division. During my talk I will discuss how this protein 
 complex ensures error-free segregation of the duplicated chromosomes\, and
  how tumor cells may have found ways to impair CPC function. Moreover\, I 
 will show recent data from my lab suggesting that deacetylation of the CPC
  subunit INCENP is important for CPC translocation from centromeres to cen
 tral spindle in anaphase.
LOCATION:Part II Room\, Department of Genetics
END:VEVENT
END:VCALENDAR