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SUMMARY:Tips at the Edge: Regulation of Microtubule Dynamics at the Cell C
 ortex. - Professor Dr Anna Akhmanova from Cell Biology\, Faculty of Scienc
 e\, Utrech University 
DTSTART:20130314T143000Z
DTEND:20130314T153000Z
UID:TALK41993@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Microtubule plus end tracking proteins (+TIPs) are a group of 
 factors\, which specifically associate with the growing microtubule ends a
 nd regulate their dynamics and interactions with various cellular structur
 es. Recent studies showed that a sequence motif Ser-any amino acid-Ile -Pr
 o (SxIP) embedded in a basic\, serine and proline rich region can target a
  variety of proteins to microtubule ends by interacting with the members o
 f End Binding (EB) family. Since this motif is relatively short\, it can a
 rise easily during evolution\, and it is thus possible that multiple yet u
 ndiscovered EB-dependent +TIPs are encoded in mammalian genomes. In my tal
 k\, I will describe the results of our searches for EB-binding +TIPs by co
 mbining proteomics and bioinformatics approaches\, and the known +TIP func
 tions. I will focus on our recent data on the mechanisms of regulation of 
 microtubule dynamics at the cell cortex.
LOCATION:Biffen Lecture Theatre
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